Acetaldehyde-Derived Advanced Glycation End-Products Promote Alcoholic Liver Disease
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چکیده
منابع مشابه
Acetaldehyde-Derived Advanced Glycation End-Products Promote Alcoholic Liver Disease
BACKGROUND Chronic ingestion of ethanol increases acetaldehyde and leads to the production of acetaldehyde-derived advanced glycation end-products (AA-AGE). We evaluated the toxicity of AA-AGE on hepatocytes and studied the role of AA-AGE in the pathogenesis of alcoholic liver disease (ALD). METHODS Rat hepatocyte cultures were treated with N-ethyllysine (NEL) or AA-AGE and the cell viability...
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Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particula...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0070034